Sensitivity analyses were performed considering the exclusion of the RCTs with the longest exposure durations (highest number of patient-years), one study being excluded for each class of non-TNFi biological drug [20, 25, 33]. Longterm safety and efficacy of abatacept through 5 years of treatment in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor inhibitor therapy. Google Scholar. This editorial refers to Is the relationship between deprivation and outcomes in rheumatoid arthritis mediated by body mass index? 2023;62:23942401. PubMed 2011;70:20037. the productivity and citation impact of the publications of a Additionally, we did not evaluate the impact of different dosing or posology used across RCTs to improve the clustering. 2008;59:78593. Schoels M, Aletaha D, Smolen JS, Wong JB. However, whereas associations have been shown between weight loss (whether through exercise or nutrition or bariatric surgery [12]) and improvement of disease activity in RA, the effect of these interventions in different socioeconomic groups is not known, calling for more research in this area. Arthritis & Rheumatology - Wikipedia Arthritis & Rheumatology: Vol 75, No 6 Volume 75, Issue 6 Pages: 867-1082 June 2023 Previous Issue GO TO SECTION Export Citation (s) Issue Information Free Access Issue Information First Published: 30 May 2023 PDF Request permissions In This Issue Free Access In This Issue First Published: 30 May 2023 PDF Request permissions Journal Club Research 8 June 2023 Four-years retention rate of golimumab administered after discontinuation of non-TNF inhibitors in patients with inflammatory rheumatic diseases Manuel Pombo-Surez, Daniel Seoane-Mato, Federico Daz-Gonzlez, Fernando Snchez-Alonso, Marta Snchez-Jareo, Luis Cea-Calvo and Isabel Castrejn Research 7 June 2023 Arthritis Research and Therapy - Impact Factor, Overall - Resurchify BMC Med Res Methodol. Joint Bone Spine. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. Please check for further notifications by email. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. A systematic literature review and meta-analysis, Early Rheumatoid Arthritis Study and the Early Rheumatoid Arthritis Network, The association of obesity with disease activity, functional ability and quality of life in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Study/Early Rheumatoid Arthritis Network UK prospective cohorts, Inflammation, obesity and rheumatic disease: common mechanistic links. Latest tweets Tweets by RheumJnl . suggests that in people living in more deprived areas, obesity further associates with worse disease outcomes. With the present results, it is advisable to evaluate the introduction ABA or RTX before TCZ in refractory RA. LMHM: Has received personal or institutional support from AbbVie, Janssen, Pfizer and Roche; has delivered speeches at events related to this work and sponsored by AbbVie, Janssen, Pfizer, Roche and UCB. Cite this article. In this model, rituximab did not modify the chance of achieving an ACR70 response compared to abatacept (RR=1.773, 95%CI 0.11310.21, p=0.765). The first study selection stage consisted of reading the titles, further encompassing abstracts and keywords. The review was registered in PROSPERO under number CRD42020167953. Rheumatology & Autoimmunity - Wiley Online Library useof impact factors of science journals easier. Improvement in patient-reported outcomes in a rituximab trial in patients with severe rheumatoid arthritis refractory to anti-tumor necrosis factor therapy. 2008;67:151623. Cloudflare Ray ID: 7e3f69f93b2f02d7 Inclusion criteria were restricted to RCTs phase 24 designed to evaluate treatment response in individuals with RA refractory to treatment with TNFi agents or MTX. These 3 explanatory variables were found after exploring all potential predictors of ACR70 response such as percentage of women, glucocorticoid use, patients' age, MTX dose, duration of RA, baseline HAQ, baseline DAS28, study follow-up time and frequency of TNFi treatment in the control arm. The NMA showed no significant difference among the studied drugs in achieving an ACR70 response, therefore, they have a similar effectiveness, with low inconsistency, but high heterogeneity among studies. Number of Best scientists*: 119. Compared efficacy of rituximab, abatacept, and tocilizumab in patients with rheumatoid arthritis refractory to methotrexate or TNF inhibitors agents: a systematic review and network meta-analysis, https://doi.org/10.1186/s42358-023-00298-z, http://bvsms.saude.gov.br/bvs/publicacoes/diretrizes_metodologicas_sistema_grade.pdf, http://creativecommons.org/licenses/by/4.0/. Your IP: Arthritis -Impact factor 2022 - 2023 - Journal Impact Score Rheumatology & Autoimmunity, hosted by Chinese Medical Association, is a peer-reviewed, open access journal focusing on cutting-edge research in rheumatology and autoimmune diseases. It is widely recognized that treatment intervention in patients with rheumatoid arthritis (RA) at early stages is associated with improved outcomes. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. CDDF multi-Stakeholder workshop on Impact of the Microbiome on Cancer 69.163.163.2 As shown in Table 1 and, direct and indirect comparisons suggest a superiority of ABA, TCZ, or RTX vs. placebo, with TCZ showing a slightly lower magnitude of effect (HR 2.765, 95% CI 1.2406.692 p=0.009) compared to ABA (HR 3.423, 95% CI 1.422 8.709 p<0.001) and to RTX (HR 3.494, 95% CI 1.5308.658 p<0.001) in achieving ACR70 response at six months. 2. . Journal ISSN: 1462-0324 About Rheumatology Rheumatology is an international peer review journal publishing the highest quality scientific and clinical papers. EMEUNET | Top Journals in Rheumatology - EULAR Arthritis and Rheumatology 2022-2023 Journal's Impact IF is 15.483. During the extraction of information from the studies, some data were not available for all trials, and the analysis of only English published trials can generate a systematic data collection bias. No specific funding was received from any bodies in the public, commercial or not-for-profit sectors to carry out the work described in this article. Ann Rheum Dis. The ACR score measures the rheumatic disease activity and is used to measure differences in relation to the baseline, showing a good relationship with the quality of life and functionality [12]. Assessing risk of bias in included studies. This website is using a security service to protect itself from online attacks. The potentially modifiable nature of obesity and its impact not just in RA, but also in many comorbidities, which might in turn further complicate RA treatment, calls for its management to be made central to treatment strategies in RA. The ACR70 response was chosen as the primary outcome due to its high specificity in relation to the functionality and quality of life improvement [13]. Ranking & Metrics. Trial-based cost-effectiveness of abatacept for rheumatoid arthritis patients in Italy. 2023. Kivitz A, Olech E, Borofsky M, Zazueta BM, Navarro-Sarabia F, et al. J Rheumatol. The present NMA showed no significant differences between tocilizumab, abatacept and rituximab to achieve ACR70 response in six months in patients with RA refractory to methotrexate or TNFi agents, but these findings yielded high heterogeneity. Read the full text. Taking the wider perspective, according to the WHO obesity represents a global epidemic, and there is an ongoing and unmet need to tackle this epidemic. However, novel head-to-head clinical trials are still needed to confirm these findings. 2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging.. 74. Given the association between obesity and other comorbidities such as cardiovascular disease also increased in patients with RA [11], and the potential impact on treatment choice, it is necessary that obesity is adequately addressed in routine clinical care. Genovese MC, Schiff M, Luggen M, Le Bars M, Aranda R, Elegbe A, et al. In these scenarios, network meta-analysis (NMA) could allow an approach to shed light on this uncertain data. . 2016;20:1610. Sistema GRADE manual de graduao da qualidade da evidncia e fora de recomendao para tomada de deciso em sade. 2010;376:1094108. In contrast, ABA was associated with a RR of 2.217 (95% CI 1.5543.161, p for difference0.001) when compared to TCZ for achieving an ACR70 response. The action you just performed triggered the security solution. In the UK, IMDs are widely used to classify the relative deprivation (essentially a measure of poverty) of small areas or neighbourhoods in England. Arthritis and Rheumatology Impactfactor 2022-2023 | Analyse, Trend Among the 19 selected trials, 31.5% (six) included TCZ as intervention arm, 31.5% (six) included RTX as active arm, and 31.5% (six) included ABA as intervention arm. In this context, the potential role of non-biological, socioeconomic factors has been raised, leading to the exploration of new concepts and avenues for research. Ann Rheum Dis. For TCZ, six studies were selected [32,33,34,35,36,37], with 294 (18.5%) patients in the intervention arm and 97 (11%) patients in the control arm achieving an ACR70 response at six months, with a HR of 1.53 (95% CI 1.241.89 p=0.002, I2=76% p for heterogeneity<0.001) (Additional file 1: Fig. ACR70"), the lower the chance of achieving ACR70 response. Google Scholar. Statistical analysis: LSFC, ABO. 10. Discover the latest rheumatoid arthritis research from Rheumatology and Rheumatology Advances in Practice. Citescore: 7.6. Best Practice & Research Clinical Rheumatology | Journal Pages: 207-447 February 2023 Issue Volume 5, Issue 2 Pages: 59-102 February 2023 scijournal.org is a platform dedicated to making the search and Lancet. BMC Rheumatology | Home - BioMed Central In this model, ABA did not modify the chance of achieving an ACR70 response when compared to RTX (1.773, 95% CI 0.11310.21, p=0.765). ; Oxford University Press is a department of the University of Oxford. Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: two-year efficacy and safety findings from AMPLE trial. Our Immediacy Index (average number of times an article is cited in the year it is published) has also increased from 0.568 to 1.236. Arthritis & Rheumatology: Vol 75, No 6 - Wiley Online Library Secretaria de Cincia, Tecnologia e Insumos Estratgicos. volume63, Articlenumber:30 (2023) Google Scholar. Arthritis & Rheumatology - Wiley Online Library explore the relationships between deprivation (used as a proxy for socioeconomic status) and obesity with self-reported disability and disease activity in RA [2]. 2007;56:1320. As shown in Table 1, the exclusion of such studies did not modify the results. BMJ. Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial. Social factors play a crucial role as shown increasingly by a large body of evidence . However, it is also known that obesity is socially patterned, so targeting those most at risk, including those of lower socioeconomic status through public health campaigns, self-management interventions [8] and other lifestyle changes [9] will likely be of benefit. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Article Patients who did not achieve at least an ACR20 response were considered refractory. Show reviews 1 Review this journal Editor login. 2019;364:l67. Editor's Pick for May 2023: Association of Gout Polygenic Risk Score With Age at Disease Onset and Tophaceous Disease in European and Polynesian Men With Gout Nicholas A. Sumpter et al. PubMed Central Researchers may also consider the practical aspect of a journal such as publication fees, acceptance rate, review speed. Comparative effectiveness of rituximab, abatacept, and tocilizumab in adults with rheumatoid arthritis and inadequate response to TNF inhibitors: prospective cohort study. S4B). When adjusted to the baseline quality of life, follow-up time, and presence of TNFi therapies in the control arm, meta-regressions showed that the use of ABA increased the chance of achieving an ACR70 response by 2.2-fold compared to the use of TCZ, with a low heterogeneity and a high explanatory power (R2>80%).
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